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Functional Screen for Genes Responsible for Tamoxifen Resistance in Human Breast Cancer Cells

1 Jun 2006

Abstract excerpt

Antiestrogens, such as tamoxifen, are widely used for endocrine treatment of estrogen receptor-positive breast cancer. However, as breast cancer progresses, development of tamoxifen resistance is inevitable. The mechanisms underlying this resistance are not well understood. To identify genes involved in tamoxifen resistance, we have developed a rapid screening method. To alter the tamoxifen-sensitive phenotype of...

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PMID: 16778085
DOI: 10.1158/1541-7786.mcr-05-0156

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