Article
Molecular mechanisms of resistance to tamoxifen therapy in breast cancer.
Archives of surgery (Chicago, Ill. : 1960) - 1 Nov 1993
Morrow M, Jordan V C
Abstract excerpt
Clinical data suggest that the use of adjuvant tamoxifen citrate (Nolvadex) for a minimum of 5 years, and possibly indefinitely, will result in maximal antitumor benefit. There is concern that long-term tamoxifen maintenance therapy may result in the induction of drug resistance. This article rev...
Topics
- Binding, Competitive
- Breast Neoplasms
- Chemotherapy, Adjuvant
- Drug Resistance
- Estrogens
- Female
- Humans
- Isomerism
- Menopause
- Molecular Biology
- Mutation
- Neoplasm Staging
- Receptors, Estrogen
- Signal Transduction
- Tamoxifen
- Time Factors
- Transcription, Genetic