Article
Estrogen receptor gene analysis in estrogen receptor-positive and receptor-negative primary breast cancer.
Journal of the National Cancer Institute - 15 Mar 1995
Roodi N, Bailey L R, Kao W Y, Verrier C S, Yee C J, Dupont W D, Parl F F
Abstract excerpt
BACKGROUND: In breast cancer patients, about two thirds of the tumors are estrogen receptor (ER)-positive and one third are ER-negative. The molecular mechanisms leading to the ER-negative phenotype are poorly understood. Nearly all ER-negative and about 40% of ER-positive cancers are resistant t...
Topics
- Base Sequence
- Breast Neoplasms
- Electrophoresis, Polyacrylamide Gel
- Female
- Gene Amplification
- Gene Deletion
- Humans
- Molecular Sequence Data
- Mutation
- Phenotype
- Point Mutation
- RNA, Messenger
- RNA, Neoplasm
- Receptors, Estrogen
- Transcription, Genetic