Article
Estrogen receptor mRNA splice variants in pre- and postmenopausal human endometrium and endometrial carcinoma.
Gynecologic oncology - 1 Apr 1997
Rice L W, Jazaeri A A, Shupnik M A
Abstract excerpt
Breast cancer tissue has been shown to contain alternatively spliced estrogen receptor (ER) mRNA variants which may result in alternate ER proteins. These ER variants lack specific functional domains and may alter breast cancer cells responses to both estrogen and antiestrogens. Specifically, ER...
Topics
- Adenocarcinoma
- Base Sequence
- Blotting, Southern
- DNA
- DNA, Neoplasm
- Endometrial Neoplasms
- Endometrium
- Exons
- Female
- Gene Deletion
- Genetic Variation
- Humans
- Polymerase Chain Reaction