Structural and biologic properties of a human aspartic acid-126 interleukin-2 analog.

doi:10.1006/abbi.1993.1608

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Article

Structural and biologic properties of a human aspartic acid-126 interleukin-2 analog.

Archives of biochemistry and biophysics - 1 Dec 1993

Buchli P, Ciardelli T

Abstract excerpt

Point mutations at position 141 in the murine interleukin-2 (IL-2) sequence have been reported to generate proteins with full antagonist activity on some IL-2-dependent cell lines. To evaluate the potential therapeutic utility of this observation, we have prepared recombinant human IL-2 with a po...

Topics

Animals
Aspartic Acid
Binding, Competitive
Biological Assay
Circular Dichroism
Humans
Interleukin-2
Mice
Mutation
Receptors, Interleukin-2
Recombinant Proteins

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