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Article

Structural and biologic properties of a human aspartic acid-126 interleukin-2 analog.

Archives of biochemistry and biophysics - 1 Dec 1993

Buchli P, Ciardelli T

Abstract excerpt

Point mutations at position 141 in the murine interleukin-2 (IL-2) sequence have been reported to generate proteins with full antagonist activity on some IL-2-dependent cell lines. To evaluate the potential therapeutic utility of this observation, we have prepared recombinant human IL-2 with a point mutation at the corresponding position (Asp for Gln 126) and examined its structural and biologic properties. This...

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Source

Identifiers

PMID: 8274030
DOI: 10.1006/abbi.1993.1608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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