Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of NH(2)-terminal amino acid residues essential for the biological activity of leukotactin-1.

Immunology letters - 15 Jun 2005

Lee Jae Kwon, Kim Hyeon Seon, Im Sun-A, Kim Kyungjae, Kwon Byoung S, Lee Chong-Kil

Abstract excerpt

Leukotactin-1 (Lkn-1), a human CC chemokine that binds to both CC chemokine receptor (CCR)1 and CCR3, is distinct from other human CC chemokines in that it has long amino acid residues preceding the first cysteine at the NH(2)-terminus. Serial deletion studies showed that at least three amino acid residues, alanine-alanine-aspartic acid (A-A-D), preceding the first cysteine at the NH(2)-terminus are essential for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alanine
Share to Aspartic Acid
Share to Calcium

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chemokines, CC

Share to Chemotaxis

Share to Macrophage Inflammatory Proteins

Share to Protein Serine-Threonine Kinases

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 15894113
DOI: 10.1016/j.imlet.2005.01.003

Genes

CCR1
CCR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of NH(2)-terminal amino acid residues essential for the biological activity of leukotactin-1.PMID 15894113Read ↗

Molecular cloning and functional characterization of human lymphotactinSemantic proximity Read ↗

Identification of receptor binding and activation determinants in the N-terminal and N-loop regions of the CC chemokine eotaxin.Semantic proximity Read ↗

Identification and characterization of a glycosaminoglycan recognition element of the C chemokine lymphotactin.Semantic proximity Read ↗

Mapping of MCP-1 functional domains by peptide analysis and site-directed mutagenesis.Semantic proximity Read ↗

Alanine scanning mutagenesis of the chemokine receptor CCR3 reveals distinct extracellular residues involved in recognition of the eotaxin family of chemokines.Semantic proximity Read ↗

Limited and defined truncation at the C terminus enhances receptor binding and degranulation activity of the neutrophil-activating peptide 2 (NAP-2). Comparison of native and recombinant NAP-2 variants.Semantic proximity Read ↗

Molecular characterization of the NCoA-1-STAT 6 interaction.Semantic proximity Read ↗

Differential activity and selectivity of N-terminal modified CXCL12 chemokines at the CXCR4 and ACKR3 receptors.Semantic proximity Read ↗

Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists.Semantic proximity Read ↗

The amino terminus and the third extracellular loop of CX3CR1 contain determinants critical for distinct receptor functions.Semantic proximity Read ↗

Importance of the carboxy-terminus of human interleukin-11 in conserving its biological activity.Semantic proximity Read ↗

Species and subtype variants of the N-formyl peptide chemotactic receptor reveal multiple important functional domains.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.