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Article

Effects of IL-1 muteins on cartilage degradation and as inducers of acute inflammation.

Agents and actions - 1 Sept 1991

Pratta M A, Arner E C, Rule B L, Galbraith W

Abstract excerpt

IL-1 peptides with N-terminal amino acid mutations were cloned and expressed to help characterize structural requirements for activity. Addition of Thr-Asn to the N-terminus (DP516) or substitution of the first two residues (Ala-Pro) of mature, native IL-1 beta with Thr-Met (DuP118) had no effect on the potency of the muteins in stimulating proteoglycan breakdown and inhibiting proteoglycan synthesis in vitro, or...

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PMID: 1793052
DOI: 10.1007/BF01993238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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