Article
Effects of IL-1 muteins on cartilage degradation and as inducers of acute inflammation.
Agents and actions - 1 Sept 1991
Pratta M A, Arner E C, Rule B L, Galbraith W
Abstract excerpt
IL-1 peptides with N-terminal amino acid mutations were cloned and expressed to help characterize structural requirements for activity. Addition of Thr-Asn to the N-terminus (DP516) or substitution of the first two residues (Ala-Pro) of mature, native IL-1 beta with Thr-Met (DuP118) had no effect on the potency of the muteins in stimulating proteoglycan breakdown and inhibiting proteoglycan synthesis in vitro, or...
Topics
- Amino Acid Sequence
- Animals
- Cartilage
- Cattle
- Inflammation
- Interleukin-1
- Male
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Mutation
- Organ Culture Techniques