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Article

Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry.

FEBS letters - 10 Jul 2003

Hatse Sigrid, Princen Katrien, Vermeire Kurt, Gerlach Lars-Ole, Rosenkilde Mette M, Schwartz Thue W, Bridger Gary, De Clercq Erik, Schols Dominique

Abstract excerpt

The interaction of the CXCR4 antagonist AMD3100 with its target is greatly influenced by specific aspartate residues in the receptor protein, including Asp(171) and Asp(262). We have now found that aspartate-to-asparagine substitutions at these positions differentially affect the binding of four different anti-CXCR4 monoclonal antibodies as well as the infectivity of diverse human immunodeficiency virus type 1...

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Source

Identifiers

PMID: 12832058
DOI: 10.1016/s0014-5793(03)00609-4

Genes

CXCR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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