Triple aminoacylation specificity of a chimerized transfer RNA.

doi:10.1021/bi00213a039

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Article

Triple aminoacylation specificity of a chimerized transfer RNA.

Biochemistry - 21 Dec 1993

Frugier M, Florentz C, Schimmel P, Giegé R

Abstract excerpt

We report here the rational design and construction of a chimerized transfer RNA with tripartite aminoacylation specificity. A yeast aspartic acid specific tRNA was transformed into a highly efficient acceptor of alanine and phenylalanine and a moderate acceptor of valine. The transformation was...

Topics

Acylation
Alanine
Base Sequence
Chimera
Escherichia coli
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Phenylalanine
RNA, Transfer, Asp
Saccharomyces cerevisiae
Valine

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