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Article

Triple aminoacylation specificity of a chimerized transfer RNA.

Biochemistry - 21 Dec 1993

Frugier M, Florentz C, Schimmel P, Giegé R

Abstract excerpt

We report here the rational design and construction of a chimerized transfer RNA with tripartite aminoacylation specificity. A yeast aspartic acid specific tRNA was transformed into a highly efficient acceptor of alanine and phenylalanine and a moderate acceptor of valine. The transformation was guided by available knowledge of the requirements for aminoacylation by each of the three amino acids and was achieved...

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PMID: 8268184
DOI: 10.1021/bi00213a039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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