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Article

Importance of single molecular determinants in the fidelity of expanded genetic codes.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2011

Antonczak Alicja K, Simova Zuzana, Yonemoto Isaac T, Bochtler Matthias, Piasecka Anna, Czapinska Honorata, Brancale Andrea, Tippmann Eric M

Abstract excerpt

The site-selective encoding of noncanonical amino acids (NAAs) is a powerful technique for the installation of novel chemical functional groups in proteins. This is often achieved by recoding a stop codon and requires two additional components: an evolved aminoacyl tRNA synthetase (AARS) and a cognate tRNA. Analysis of the most successful AARSs reveals common characteristics. The highest fidelity NAA systems...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21224416
DOI: 10.1073/pnas.1012276108
PMCID: PMC3029751

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Source receipt: pubmed, retrieved 7 Sept 2026.

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