Mutational isolation of a sieve for editing in a transfer RNA synthetase.

doi:10.1126/science.8146659

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Article

Mutational isolation of a sieve for editing in a transfer RNA synthetase.

Science (New York, N.Y.) - 8 Apr 1994

Schmidt E, Schimmel P

Abstract excerpt

Editing reactions are essential for the high fidelity of information transfer in processes such as replication, RNA splicing, and protein synthesis. The accuracy of interpretation of the genetic code is enhanced by the editing reactions of aminoacyl transfer RNA (tRNA) synthetases, whereby amino...

Topics

Adenosine Triphosphate
Binding Sites
Escherichia coli
Isoleucine
Isoleucine-tRNA Ligase
Kinetics
Mutation
Protein Structure, Secondary
RNA Editing
RNA, Transfer, Ile
Valine

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