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Article

Mutational isolation of a sieve for editing in a transfer RNA synthetase.

Science (New York, N.Y.) - 8 Apr 1994

Schmidt E, Schimmel P

Abstract excerpt

Editing reactions are essential for the high fidelity of information transfer in processes such as replication, RNA splicing, and protein synthesis. The accuracy of interpretation of the genetic code is enhanced by the editing reactions of aminoacyl transfer RNA (tRNA) synthetases, whereby amino acids are prevented from being attached to the wrong tRNAs. Amino acid discrimination is achieved through sieves that...

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PMID: 8146659
DOI: 10.1126/science.8146659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Mutational isolation of a sieve for editing in a transfer RNA synthetase.PMID 8146659Read ↗

Mutational unmasking of a tRNA-dependent pathway for preventing genetic code ambiguity.Semantic proximity Read ↗

Genetic code ambiguity. Cell viability related to the severity of editing defects in mutant tRNA synthetases.Semantic proximity Read ↗

Interstice mutations that block site-to-site translocation of a misactivated amino acid bound to a class I tRNA synthetase.Semantic proximity Read ↗

Enlarging the amino acid set of Escherichia coli by infiltration of the valine coding pathway.Semantic proximity Read ↗

Post-transfer editing in vitro and in vivo by the beta subunit of phenylalanyl-tRNA synthetase.Semantic proximity Read ↗

Role of tRNA amino acid-accepting end in aminoacylation and its quality control.Semantic proximity Read ↗

An isolated class II aminoacyl-tRNA synthetase insertion domain is functional in amino acid editing.Semantic proximity Read ↗

Partitioning of tRNA-dependent editing between pre- and post-transfer pathways in class I aminoacyl-tRNA synthetases.Semantic proximity Read ↗

A glycine hinge for tRNA-dependent translocation of editing substrates to prevent errors by leucyl-tRNA synthetase.Semantic proximity Read ↗

Elucidation of tRNA-dependent editing by a class II tRNA synthetase and significance for cell viability.Semantic proximity Read ↗

Transfer RNA-mediated editing in threonyl-tRNA synthetase. The class II solution to the double discrimination problem.Semantic proximity Read ↗

Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase.Semantic proximity Read ↗

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