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Article

RNA recognition by designed peptide fusion creates "artificial" tRNA synthetase.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2003

Frugier Magali, Giege Richard, Schimmel Paul

Abstract excerpt

The genetic code was established through aminoacylations of RNA substrates that emerged as tRNAs. The 20 aminoacyl-tRNA synthetases (one for each amino acid) are ancient proteins, the active-site domain of which catalyzes formation of an aminoacyl adenylate that subsequently reacts with the 3' end of bound tRNA. Binding of tRNA depends on idiosyncratic (to the particular synthetase) domains and motifs that are...

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Identifiers

PMID: 12796515
DOI: 10.1073/pnas.1332771100
PMCID: PMC164610

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Source receipt: pubmed, retrieved 7 Sept 2026.

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