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Article

Eight base changes are sufficient to convert a leucine-inserting tRNA into a serine-inserting tRNA.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 1992

Normanly J, Ollick T, Abelson J

Abstract excerpt

Each aminoacyl-tRNA synthetase must functionally distinguish its cognate tRNAs from all others. We have determined the minimum number of changes required to transform a leucine amber suppressor tRNA to serine identity. Eight changes are required. These are located in the acceptor stem and in the D stem.

Topics

Base Composition
Base Sequence
Escherichia coli
Genes, Synthetic
Genetic Variation
Molecular Sequence Data
Nucleic Acid Conformation
Oligodeoxyribonucleotides
Plasmids
RNA, Transfer, Leu
RNA, Transfer, Ser

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Suppression, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1608979
DOI: 10.1073/pnas.89.12.5680
PMCID: PMC49356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1608979-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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