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Article

Peptide translocation by variants of the transporter associated with antigen processing.

Science (New York, N.Y.) - 24 Dec 1993

Heemels M T, Schumacher T N, Wonigeit K, Ploegh H L

Abstract excerpt

Major histocompatibility complex (MHC) class I molecules associate with peptides that are delivered from the cytosol to the lumen of the endoplasmic reticulum by the transporter associated with antigen processing (TAP). Liver microsomes of SHR and Lewis rats, which express different alleles of TAP (cim(b) and cim(a), respectively), accumulate different sets of peptides. Use of MHC congenic rats assigned this...

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Identifiers

PMID: 8266106
DOI: 10.1126/science.8266106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Peptide translocation by variants of the transporter associated with antigen processing.PMID 8266106Read ↗

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Co-evolution of rat TAP transporters and MHC class I RT1-A molecules.Semantic proximity Read ↗

Selection and binding of peptides to human transporters associated with antigen processing and rat cim-a and -b.Semantic proximity Read ↗

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Functional analysis by site-directed mutagenesis of the complex polymorphism in rat transporter associated with antigen processing.Semantic proximity Read ↗

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