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Article

Functional analysis by site-directed mutagenesis of the complex polymorphism in rat transporter associated with antigen processing.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1998

Deverson E V, Leong L, Seelig A, Coadwell W J, Tredgett E M, Butcher G W, Howard J C

Abstract excerpt

The transporter associated with Ag processing, TAP, is an endoplasmic reticulum resident heterodimeric member of the ATP-binding cassette transporter family. TAP transports short peptides from cytosol to the endoplasmic reticulum lumen for loading into recently synthesized class I MHC molecules. In the rat, two alleles of the TAP2 chain differ in their permissiveness to the transport of peptides with small...

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Source

Identifiers

PMID: 9510178

Genes

TAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analysis by site-directed mutagenesis of the complex polymorphism in rat transporter associated with antigen processing.PMID 9510178Read ↗

A point mutation in the human transporter associated with antigen processing (TAP2) alters the peptide transport specificity.Semantic proximity Read ↗

Absence of functional relevance of human transporter associated with antigen processing polymorphism for peptide selection.Semantic proximity Read ↗

The rat cim effect: TAP allele-dependent changes in a class I MHC anchor motif and evidence against C-terminal trimming of peptides in the ER.Semantic proximity Read ↗

Polymorphism in transporter associated proteins within an antigen processing (TAP2) gene located in the HLA class II region.Semantic proximity Read ↗

Allelic variation in the mouse Tap-1 and Tap-2 transporter genes.Semantic proximity Read ↗

Co-evolution of rat TAP transporters and MHC class I RT1-A molecules.Semantic proximity Read ↗

Polymorphisms involving the transmembrane domains of human TAP2.Semantic proximity Read ↗

Mutant MHC class I molecules define interactions between components of the peptide-loading complex.Semantic proximity Read ↗

Substrate specificity of allelic variants of the TAP peptide transporter.Semantic proximity Read ↗

Genetics of antigen processing and presentationSemantic proximity Read ↗

Transporters from H-2b, H-2d, H-2s, H-2k, and H-2g7 (NOD/Lt) haplotype translocate similar sets of peptides.Semantic proximity Read ↗

A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing.Semantic proximity Read ↗

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