Article
Functional analysis by site-directed mutagenesis of the complex polymorphism in rat transporter associated with antigen processing.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1998
Deverson E V, Leong L, Seelig A, Coadwell W J, Tredgett E M, Butcher G W, Howard J C
Abstract excerpt
The transporter associated with Ag processing, TAP, is an endoplasmic reticulum resident heterodimeric member of the ATP-binding cassette transporter family. TAP transports short peptides from cytosol to the endoplasmic reticulum lumen for loading into recently synthesized class I MHC molecules....
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Alleles
- Amino Acid Sequence
- Animals
- Antigen Presentation
- Cell Line
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Polymorphism, Genetic
- Rats
- Structure-Activity Relationship
- T-Lymphocytes, Cytotoxic