Article
Rat MHC-linked peptide transporter alleles strongly influence peptide binding by HLA-B27 but not B27-associated inflammatory disease.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1996
Simmons W A, Leong L Y, Satumtira N, Butcher G W, Howard J C, Richardson J A, Slaughter C A, Hammer R E, Taurog J D
Abstract excerpt
Rats transgenic for the human MHC molecule HLA-B27 were used to study the effect of two alleles, cima and cimb, which are associated with peptide transport by the MHC-encoded Tap2 transporter, on the function of HLA-B27 as a restriction element for CTL recognition of the male H-Y minor H Ag and on the multisystem inflammatory disease characteristic of B27 transgenic rats. Anti-H-Y CTL generated in cima B27...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Alleles
- Animals
- Animals, Genetically Modified
- Antigen-Presenting Cells
- Female
- H-Y Antigen
- HLA-B27 Antigen