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Article

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells.

Nature - 31 Jul 1997

Grawunder U, Wilm M, Wu X, Kulesza P, Wilson T E, Mann M, Lieber M R

Abstract excerpt

Mutation of the XRCC4 gene in mammalian cells prevents the formation of the signal and coding joints in the V(D)J recombination reaction, which is necessary for production of a functional immunoglobulin gene, and renders the cells highly sensitive to ionizing radiation. However, XRCC4 shares no s...

Topics

Animals
CHO Cells
Cloning, Molecular
Cricetinae
DNA
DNA Ligase ATP
DNA Ligases
DNA-Binding Proteins
Enzyme Activation
Humans
Mammals
Mutation
Recombinant Fusion Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombination, Genetic

Transfection

Source

Identifiers

PMID: 9242410
DOI: 10.1038/41358

Genes

XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9242410-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells.PMID 9242410Read ↗

Structural and Functional Interaction between the Human DNA Repair Proteins DNA Ligase IV and XRCC4Semantic proximity Read ↗

Impact of DNA ligase IV on the fidelity of end joining in human cells.Semantic proximity Read ↗

Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeuticsSemantic proximity Read ↗

XRCC4's interaction with XLF is required for coding (but not signal) end joining.Semantic proximity Read ↗

Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF.Semantic proximity Read ↗

Identification of Genes Involved in Repair of DNA Double-Strand Breaks in Mammalian CellsSemantic proximity Read ↗

Ligase IV syndrome.Semantic proximity Read ↗

DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes.Semantic proximity Read ↗

C-Terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin.Semantic proximity Read ↗

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice.Semantic proximity Read ↗

Altered DNA ligase activity in human diseaseSemantic proximity Read ↗

Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity.Semantic proximity Read ↗

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