Article
Motif A of bacteriophage T4 DNA polymerase: role in primer extension and DNA replication fidelity. Isolation of new antimutator and mutator DNA polymerases.
The Journal of biological chemistry - 25 Feb 1994
Reha-Krantz L J, Nonay R L
Abstract excerpt
Polymerases in general share only a few regions of amino acid similarity. One of the most conserved regions, called motif A, has the sequence DXXSLYPSII or a similar sequence in many eukaryotic and viral DNA polymerases and in bacteriophage T4 DNA polymerase. We designed genetic techniques to iso...
Topics
- Amino Acid Sequence
- Amino Acids
- Bacteriophage T4
- Base Sequence
- DNA Primers
- DNA Replication
- DNA, Viral
- DNA-Directed DNA Polymerase
- Escherichia coli
- Molecular Sequence Data
- Mutation
- Nucleic Acid Synthesis Inhibitors