Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The clinical significance of p53 aberrations in human tumours.

Virchows Archiv : an international journal of pathology - 1 Jan 1995

Bosari S, Viale G

Abstract excerpt

p53 aberrations are the most common genetic alteration found in human tumours and this review summarizes the current understanding of the clinical significance of p53 abnormalities. Immunohistochemical and molecular techniques can demonstrate alterations at the protein and gene level, respectively, but with a significant discordance between the findings of either technique. The tumours evaluated in this review...

Topics

Chromosome Aberrations
Humans
Immunohistochemistry
Mutation
Neoplasms
Tumor Suppressor Protein p53

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7496591
DOI: 10.1007/BF00203389

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7496591-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The clinical significance of p53 aberrations in human tumours.PMID 7496591Read ↗

Clinical outcomes and correlates of TP53 mutations and cancer.Semantic proximity Read ↗

p53 alterations in human cancer: more questions than answers.Semantic proximity Read ↗

Clinical implications of p53 mutations.Semantic proximity Read ↗

The significance of p53 mutations in human cancers.Semantic proximity Read ↗

Exploiting the p53 pathway for the diagnosis and therapy of human cancer.Semantic proximity Read ↗

P53 gene mutations: case study of a clinical marker for solid tumors.Semantic proximity Read ↗

p53: an overview of over two decades of study.Semantic proximity Read ↗

P53 gene alterations in human tumors: perspectives for cancer control.Semantic proximity Read ↗

p53 family members in cancer diagnosis and treatment.Semantic proximity Read ↗

P53 mutation in a series of epithelial ovarian cancers from the U.K., and its prognostic significance.Semantic proximity Read ↗

Overexpression of p53 protein in human tumors.Semantic proximity Read ↗

The importance of p53 gene alterations in human cancer: is there more than circumstantial evidence?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.