Article
Prognostic value of p53 molecular status in high-risk primary breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 May 2003
Marchetti P, Cannita K, Ricevuto E, De Galitiis F, Di Rocco Z C, Tessitore A, Bisegna R, Porzio G, De Rubeis G P, Ventura T, Martinotti S, Ficorella C
Abstract excerpt
BACKGROUND: Mutations in the p53 gene are the most common genetic alterations in human primary breast carcinoma and these mutations are often associated with worse prognosis and chemo/radioresistance. PATIENTS AND METHODS: The analysis of the p53 gene was performed by fluorescence-assisted mismatch analysis in 13 consecutive high-risk primary breast cancer (HR-BC) patients with 10 or more involved axillary nodes...
Topics
- Breast Neoplasms
- Confidence Intervals
- Female
- Follow-Up Studies
- Genes, p53
- Humans
- Mutation
- Prognosis
- Risk Factors