p53 in breast cancer: mutation and countermeasures.

Abstract excerpt

p53 is the primary arbiter of the mammalian cell's response to stress, the governor of life and death. It is the nexus upon which signals converge from an array of sensors that detect damage to DNA or to the mitotic spindle or the cytoskeleton, hypoxia, cell detachment, growth factor deprivation, oncogene expression and other forms of stress. Depending on the type, intensity and duration of the signals, p53 in...

Topics

• Breast Neoplasms
• Female
• Genes, p53
• Genetic Therapy
• Humans
• Mutation