Both amino acid changes in nsP1 of Sindbis virusLM21 contribute to and are required for efficient expression of the mutant phenotype.

doi:10.1016/0042-6822(90)90340-w

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Article

Both amino acid changes in nsP1 of Sindbis virusLM21 contribute to and are required for efficient expression of the mutant phenotype.

Virology - 1 Oct 1990

Mi S, Stollar V

Abstract excerpt

SVLM21 is a mutant of Sindbis virus which in contrast to the standard virus, SVSTD, is able to replicate in Aedes albopictus mosquito cells deprived of methionine. Previously, by making use of the infectious Toto plasmids, we had constructed recombinant viruses containing various SVLM21 sequences...

Topics

Aedes
Animals
Chick Embryo
Drug Resistance, Microbial
Fibroblasts
Gene Expression Regulation, Viral
Methionine
Mutation
Phenotype
Sindbis Virus
Virus Replication
tRNA Methyltransferases

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