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Article

Modification of Asn374 of nsP1 Suppresses a Sindbis Virus nsP4 Minus-Strand Polymerase Mutant

1 Sept 2002

Abstract excerpt

Our recent study (C. L. Fata, S. G. Sawicki, and D. L. Sawicki, J. Virol. 76:8632-8640, 2002) found minus-strand synthesis to be temperature sensitive in vertebrate and invertebrate cells when the Arg183 residue of the Sindbis virus nsP4 polymerase was changed to Ser, Ala, or Lys. Here we report the results of studies identifying an interacting partner of the region of the viral polymerase containing Arg183 that...

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Identifiers

PMID: 12163583
DOI: 10.1128/jvi.76.17.8641-8649.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Modification of Asn374 of nsP1 Suppresses a Sindbis Virus nsP4 Minus-Strand Polymerase MutantPMID 12163583Read ↗

Suppressor mutations that allow sindbis virus RNA polymerase to function with nonaromatic amino acids at the N-terminus: evidence for interaction between nsP1 and nsP4 in minus-strand RNA synthesis.Semantic proximity Read ↗

Alphavirus minus-strand RNA synthesis: identification of a role for Arg183 of the nsP4 polymerase.Semantic proximity Read ↗

Temperature sensitive shut-off of alphavirus minus strand RNA synthesis maps to a nonstructural protein, nsP4.Semantic proximity Read ↗

Requirement for an aromatic amino acid or histidine at the N terminus of Sindbis virus RNA polymerase.Semantic proximity Read ↗

Mutations which alter the level or structure of nsP4 can affect the efficiency of Sindbis virus replication in a host-dependent manner.Semantic proximity Read ↗

An attenuating mutation in nsP1 of the Sindbis-group virus S.A.AR86 accelerates nonstructural protein processing and up-regulates viral 26S RNA synthesis.Semantic proximity Read ↗

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Mutagenesis of the conserved 51-nucleotide region of Sindbis virus.Semantic proximity Read ↗

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