Article
Engraftment of human synovium into severe combined immune deficient mice. Migration of human peripheral blood T cells to engrafted human synovium and to mouse lymph nodes.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1993
Rendt K E, Barry T S, Jones D M, Richter C B, McCachren S S, Haynes B F
Abstract excerpt
To determine the feasibility of using the C.B-17 scid/scid (severe combined immune deficient, SCID) mouse as a recipient of human synovial xenografts, we have engrafted human synovium under the renal capsule of SCID mice, and determined synovial graft survival and histologic characteristics 4 to 7 wk after tissue implantation. Both normal and inflammatory synovial tissue grew well in SCID mice and maintained...
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