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Article

Human T cells in the SCID-hu mouse are phenotypically normal and functionally competent.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1991

Krowka J F, Sarin S, Namikawa R, McCune J M, Kaneshima H

Abstract excerpt

SCID-hu mice are heterochimeric animals that are constructed by transplanting human fetal thymus (Thy), liver (Liv), and/or lymph nodes into congenitally immunodeficient C.B-17 scid/scid (SCID) mice. Sensitive and specific two-color flow cytometric assays were used to evaluate human lymphocytes from peripheral blood of SCID-hu mice. Kinetic studies presented in this report show long term T lymphopoiesis in...

Topics

Animals
Antigens, CD
Antigens, Differentiation
Antigens, Differentiation, T-Lymphocyte
Fetus
Histocompatibility Antigens
Histocompatibility Antigens Class I
Humans
Immunologic Deficiency Syndromes
Lectins, C-Type

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukocyte Common Antigens

Liver Transplantation

Lymphocyte Activation

Mice

Phenotype

Receptors, Interleukin-2

T-Lymphocytes

Thymus Gland

Source

Identifiers

PMID: 1827814

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1827814-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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