Reversion of the SCID phenotype by human T cell grafts. Development of cross-species immunocompetence.

Article

Reversion of the SCID phenotype by human T cell grafts. Development of cross-species immunocompetence.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1993

Donjon C M, Morkowski H, Cheung R K, Leeder J S, Dosch H M

Abstract excerpt

Due to defective recombinase function, mice with severe combined immunodeficiency (SCID) lack functional lymphocytes and can accept human lymphoid xenografts. Xenografted animals (SCIDhum) are thought to provide a neutral environment for in vivo studies of normal, malignant or HIV-infected human...

Topics

Animals
Cell Line, Transformed
Herpesvirus 4, Human
Humans
Immunocompetence
Lymphoma
Mice
Mice, SCID
Phenotype
T-Lymphocytes
Transplantation, Heterologous
Tumor Virus Infections

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