Article
Reversion of the SCID phenotype by human T cell grafts. Development of cross-species immunocompetence.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1993
Donjon C M, Morkowski H, Cheung R K, Leeder J S, Dosch H M
Abstract excerpt
Due to defective recombinase function, mice with severe combined immunodeficiency (SCID) lack functional lymphocytes and can accept human lymphoid xenografts. Xenografted animals (SCIDhum) are thought to provide a neutral environment for in vivo studies of normal, malignant or HIV-infected human cells. SCIDhum often develop endogenous, EBV+ lymphomas in the graft and in the our study two-thirds of 142 SCIDhum...
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