Article
Human peripheral blood xenografts in the SCID mouse: characterization of immunologic reconstitution.
The Journal of infectious diseases - 1 Sept 1993
Hesselton R M, Koup R A, Cromwell M A, Graham B S, Johns M, Sullivan J L
Abstract excerpt
Immune reconstitutions (hu-PBL-SCID mice) resulting from adoptive transfer of human peripheral blood mononuclear cells into 1800 C.B-17 scid-/scid-mice were characterized. Over 90% of reconstitutions were successful as evidenced by human immunoglobulin production. Variability was noted with donor...
Topics
- Age Factors
- Animals
- Blood Cells
- CD3 Complex
- CD4 Antigens
- CD8 Antigens
- Humans
- Immune System
- Immunoglobulins
- Leukocytes, Mononuclear
- Mice
- Mice, SCID
- Models, Biological
- Peritoneal Cavity
- Phenotype
- Receptors, Interleukin-2
- Species Specificity
- Specific Pathogen-Free Organisms