Article
THE ALLOGENEIC RESPONSE TO CULTURED HUMAN SKIN EQUIVALENT IN THE hu-PBL-SCID MOUSE MODEL OF SKIN REJECTION1
1 Jun 1999
Abstract excerpt
BACKGROUND: Engineered tissues have been proposed for the treatment of a variety of conditions including the partial or complete replacement of human organs. To determine the basis for the rejection of these tissues, we analyzed the immune response to allogeneic human skin equivalent (HSE, also called Apligraf) in the humanized SCID mouse (hu-PBL-SCID). METHODS: Two models of hu-PBL-SCID were used for these...
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