Article
Enhanced engraftment of human peripheral blood lymphocytes into anti-murine interferon-gamma monoclonal antibody-treated C.B.-17-scid mice.
Cellular immunology - 10 Jan 1998
Shibata S, Asano T, Noguchi A, Kimura H, Ogura A, Naiki M, Doi K
Abstract excerpt
To improve the engraftment of human peripheral blood lymphocytes (PBL) to severe combined immunodeficient (SCID) mice, and to elucidate the factors which prevent the PBL's survival, we treated SCID mice with mAb, which neutralizes murine IFN-gamma's ability to activate cell-mediated immunity. Com...
Topics
- Animals
- Antibodies, Monoclonal
- Cell Transplantation
- Graft Enhancement, Immunologic
- Humans
- Immunoenzyme Techniques
- Immunoglobulin G
- Immunoglobulin M
- Interferon-gamma
- Leukocytes, Mononuclear
- Lymphoid Tissue
- Mice
- Mice, SCID
- Peritoneum
- Phenotype
- Recombinant Proteins
- Spleen