Article
MCP-1 and MIP-1alpha are most efficient in recruiting T cells into the skin in vivo.
The Journal of investigative dermatology - 1 Dec 1998
Kunstfeld R, Lechleitner S, Wolff K, Petzelbauer P
Abstract excerpt
To analyze T cell recruitment by chemokines in vivo, we used SCID mice grafted with human skin onto their backs and human T cells into their peritoneal cavities. rh MIP-1alpha and rh MCP-1, as well as mouse MCP-1, attracted significant amounts of human T cells into human skin grafts, whereas effects of rh RANTES, rh SDF-1, or rh IP-10 were minimal. Human T cells were found in a striking perivascular position...
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