MCP-1 and MIP-1alpha are most efficient in recruiting T cells into the skin in vivo.

doi:10.1046/j.1523-1747.1998.00410.x

Back to search

Article

MCP-1 and MIP-1alpha are most efficient in recruiting T cells into the skin in vivo.

The Journal of investigative dermatology - 1 Dec 1998

Kunstfeld R, Lechleitner S, Wolff K, Petzelbauer P

Abstract excerpt

To analyze T cell recruitment by chemokines in vivo, we used SCID mice grafted with human skin onto their backs and human T cells into their peritoneal cavities. rh MIP-1alpha and rh MCP-1, as well as mouse MCP-1, attracted significant amounts of human T cells into human skin grafts, whereas effe...

Topics

Animals
Cell Movement
Chemokine CCL2
Chemokine CCL3
Chemokine CCL4
Chemokines
Endothelium, Vascular
Humans
Macrophage Inflammatory Proteins
Mice
Mice, SCID
Phenotype
Skin Transplantation
T-Lymphocytes
Transplantation, Heterologous

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.