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Induction of graft versus host disease in SCID mice by MRL/lpr cell transfer.

Clinical immunology and immunopathology - 1 Jun 1994

Fraziano M, Montesano C, Sammarco I, di Cesare S, Caroleo M C, Mattei M, Cannata S, Poccia F, Bellavia A, Salerno A

Abstract excerpt

We have investigated the graft versus host (GvH) disease induced in immunodeficient SCID (H-2d) mice by intravenous (iv) or intraperitoneal (ip) transfer of either spleen or lymph node cells from autoimmune (MRL/lpr and MRL/++ mice, H-2k) and normal (CBA, H-2k) mice. Rapid and lethal GvH disease was observed when cells from MRL/lpr or MRL/++ were iv transferred into SCID mice, while spleen cells from...

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Identifiers

PMID: 8200130
DOI: 10.1006/clin.1994.1085

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