Induction of graft versus host disease in SCID mice by MRL/lpr cell transfer.

doi:10.1006/clin.1994.1085

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Article

Induction of graft versus host disease in SCID mice by MRL/lpr cell transfer.

Clinical immunology and immunopathology - 1 Jun 1994

Fraziano M, Montesano C, Sammarco I, di Cesare S, Caroleo M C, Mattei M, Cannata S, Poccia F, Bellavia A, Salerno A

Abstract excerpt

We have investigated the graft versus host (GvH) disease induced in immunodeficient SCID (H-2d) mice by intravenous (iv) or intraperitoneal (ip) transfer of either spleen or lymph node cells from autoimmune (MRL/lpr and MRL/++ mice, H-2k) and normal (CBA, H-2k) mice. Rapid and lethal GvH disease was observed when cells from MRL/lpr or MRL/++ were iv transferred into SCID mice, while spleen cells from...

Topics

Animals
CD4-CD8 Ratio
Cell Transplantation
Cytotoxicity, Immunologic
Graft vs Host Disease
Graft vs Host Reaction
Immune Tolerance
Immunotherapy, Adoptive
Lymph Nodes
Mice
Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mice, Inbred CBA

Mice, Mutant Strains

Mice, SCID

Phenotype

Spleen

Source

Open in PubMed

Identifiers

PMID: 8200130
DOI: 10.1006/clin.1994.1085

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8200130-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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