Article
Direct recognition of rat MHC antigens on rat antigen-presenting cells by mouse CD4+ and CD8+ T cells and establishment of T cell clones exhibiting a direct recognition pathway.
Transplantation - 15 Mar 1997
Hirota T, Hirose H, Iwata H, Kanetake K, Murakawa S, Sasaki E, Takagi H, Bando M, Hamaoka T, Fujiwara H
Abstract excerpt
Alloantigens are recognized by T cells either through a direct pathway, which involves recognition of alloantigens expressed on allogeneic antigen-presenting cells (APC), or through an indirect pathway, which involves recognition of processed alloantigens presented by self APC. We investigated whether rat xenoantigens are also recognized by direct (xenogeneic APC-restricted) and/or indirect (self APC-restricted)...
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