Article
Autoimmunity, hyporeactivity to T cell mitogens and lymphoproliferative disorders following neonatal induction of transplantation tolerance in mice.
European journal of immunology - 1 Nov 1993
Jánossy T, Baranyi L, Knulst A C, Vizler C, Benner R, Kelényi G, Végh P
Abstract excerpt
We have reported that, in A/J (A) (H-2a) mice, a partial tolerance to C57BL/10ScSn (B10) (H-2b) skin allografts and a high incidence of lethal lymphoproliferative disorders (LPD) can be induced by the neonatal i.v. injection of 2 x 10(7) semiallogeneic (B10 x A)F1 spleen cells (SC) (Végh, P., Baranyi, L. and Jánossy, T., Cell. Immunol. 1990, 129: 56). In this study, we show that the incidence and mortality of LPD...
Topics
- Animals
- Animals, Newborn
- Autoantibodies
- Autoimmunity
- Graft Survival
- Immune Tolerance
- Lymphoproliferative Disorders
- Mice
- Mice, Inbred A
- Mice, Inbred C57BL
- Mice, Inbred CBA