Article
The concurrent maturation of mouse and human thymocytes in human fetal thymus implanted in NIH-beige-nude-xid mice is associated with the reconstitution of the murine immune system.
The Journal of experimental medicine - 1 Mar 1993
Kollmann T R, Goldstein M M, Goldstein H
Abstract excerpt
To determine whether the human thymus provides an environment for the maturation of murine T cells, human fetal thymus and liver (hu-thy/liv) were implanted into congenitally athymic NIH-beige-nude-xid (BNX) mice or C.B-17 scid/scid (SCID) mice. 3 mo after implantation, in contrast to the hu-thy/liv implant in SCID mice, which was populated only with human CD4/CD8 single- and double-positive thymocytes, the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.