The concurrent maturation of mouse and human thymocytes in human fetal thymus implanted in NIH-beige-nude-xid mice is associated with the reconstitution of the murine immune system.

doi:10.1084/jem.177.3.821

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Article

The concurrent maturation of mouse and human thymocytes in human fetal thymus implanted in NIH-beige-nude-xid mice is associated with the reconstitution of the murine immune system.

The Journal of experimental medicine - 1 Mar 1993

Kollmann T R, Goldstein M M, Goldstein H

Abstract excerpt

To determine whether the human thymus provides an environment for the maturation of murine T cells, human fetal thymus and liver (hu-thy/liv) were implanted into congenitally athymic NIH-beige-nude-xid (BNX) mice or C.B-17 scid/scid (SCID) mice. 3 mo after implantation, in contrast to the hu-thy/...

Topics

Animals
CD4 Antigens
CD8 Antigens
Cell Differentiation
Enzyme-Linked Immunosorbent Assay
Fetus
Flow Cytometry
Humans
Immune System
Immunoglobulin G
Immunohistochemistry
Liver

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Nude

Mice, SCID

Phenotype

T-Lymphocytes

Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 8436912
DOI: 10.1084/jem.177.3.821
PMCID: PMC2190942

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8436912-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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