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Article

Autoprocessing: an essential step for the activation of HIV-1 protease.

The Biochemical journal - 1 Jun 1996

Wan M, Takagi M, Loh B N, Xu X Z, Imanaka T

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) expresses its structural and functional proteins within Gag-Pol precursor polyproteins. Specific proteolytic processing of the precursors by the viral protease is critical for the maturation and infectivity of viral particles. To observe the influence of autoprocessing on the activation of recombinant HIV-1 protease, we constructed different HIV-1 protease forms, with...

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Identifiers

PMID: 8687402
DOI: 10.1042/bj3160569
PMCID: PMC1217386

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