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Article

Insights into the mechanism of SARS-CoV-2 main protease autocatalytic maturation from model precursors.

Communications biology - 13 Nov 2023

Aniana Annie, Nashed Nashaat T, Ghirlando Rodolfo, Coates Leighton, Kneller Daniel W, Kovalevsky Andrey, Louis John M

Abstract excerpt

A critical step for SARS-CoV-2 assembly and maturation involves the autoactivation of the main protease (MProWT) from precursor polyproteins. Upon expression, a model precursor of MProWT mediates its own release at its termini rapidly to yield a mature dimer. A construct with an E290A mutation within MPro exhibits time dependent autoprocessing of the accumulated precursor at the N-terminal nsp4/nsp5 site followed...

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Identifiers

PMID: 37957287
DOI: 10.1038/s42003-023-05469-8
PMCID: PMC10643566

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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