Article
The spacer peptide between human immunodeficiency virus capsid and nucleocapsid proteins is essential for ordered assembly and viral infectivity.
Journal of virology - 1 Jun 1995
Kräusslich H G, Fäcke M, Heuser A M, Konvalinka J, Zentgraf H
Abstract excerpt
Morphogenesis of retroviruses involves ordered assembly of the structural Gag- and Gag-Pol polyproteins, with subsequent budding from the plasma membrane and proteolytic cleavage by the viral proteinase (PR). Two cleavage sites exist between the capsid (CA) and nucleocapsid (NC) domains of the hu...
Topics
- Amino Acid Sequence
- Animals
- Capsid
- Cell Line
- Gene Products, gag
- HIV-1
- Hydrolysis
- Microscopy, Electron
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Protein Processing, Post-Translational
- Transfection