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Article

Mutational analysis of a native substrate of the HIV-1 proteinase.

Advances in experimental medicine and biology - 1 Jan 1991

Partin K, Wimmer E, Carter C

Abstract excerpt

The purpose of this study was to define further the determinants of substrate specificity of HIV-1 PR. Rather than using small peptides, we used an in vitro system which permitted us to evaluate the effect of a mutated site within the context of its natural precursor. We made single-amino-acid substitutions around two sites which are processed by the HIV-1 PR. The Tyr/Pro site within gag appears to encode highly...

Topics

Amino Acid Sequence
Binding Sites
Fusion Proteins, gag-pol
HIV
HIV Protease
Lentivirus
Molecular Sequence Data
Mutation
Pepsinogens
Protein Processing, Post-Translational
Sequence Homology, Nucleic Acid

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Substrate Specificity

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Identifiers

PMID: 1667451
DOI: 10.1007/978-1-4684-6012-4_65

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1667451-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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