Studies of the major reovirus core protein sigma 2: reversion of the assembly-defective mutant tsC447 is an intragenic process and involves back mutation of Asp-383 to Asn.

doi:10.1128/JVI.68.1.177-186.1994

Article

Studies of the major reovirus core protein sigma 2: reversion of the assembly-defective mutant tsC447 is an intragenic process and involves back mutation of Asp-383 to Asn.

Journal of virology - 1 Jan 1994

Coombs K M, Mak S C, Petrycky-Cox L D

Abstract excerpt

The reovirus group C temperature-sensitive mutant tsC447, whose defect maps to the S2 gene, which encodes the major core protein sigma 2, fails to assemble core particles at the nonpermissive temperature. To identify other proteins that may interact with sigma 2 during assembly, we generated and...

Topics

Animals
Asparagine
Aspartic Acid
Base Sequence
Crosses, Genetic
Genes, Suppressor
Genes, Viral
L Cells
Mammalian orthoreovirus 3
Mice
Molecular Sequence Data
Mutagenesis
Orthoreovirus
Phenotype
Reoviridae
Viral Core Proteins

Studies of the major reovirus core protein sigma 2: reversion of the assembly-defective mutant tsC447 is an intragenic process and involves back mutation of Asp-383 to Asn.

Abstract excerpt

Topics

Discuss the evidence