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Article

Identification and characterization of a double-stranded RNA- reovirus temperature-sensitive mutant defective in minor core protein mu2.

Journal of virology - 1 Jul 1996

Coombs K M

Abstract excerpt

A newly identified temperature-sensitive mutant whose defect was mapped to the reovirus M1 gene (minor core protein mu2) was studied to better understand the functions of this virion protein. Sequence determination of the Ml gene of this mutant (tsH11.2) revealed a predicted methionine-to-threonine alteration at amino acid 399 and a change from proline to histidine at amino acid 414. The mutant made normal...

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Identifiers

PMID: 8676444
DOI: 10.1128/JVI.70.7.4237-4245.1996
PMCID: PMC190354

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