Reovirus variants selected during persistent infections of L cells contain mutations in the viral S1 and S4 genes and are altered in viral disassembly.

doi:10.1128/JVI.71.2.1362-1369.1997

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Article

Reovirus variants selected during persistent infections of L cells contain mutations in the viral S1 and S4 genes and are altered in viral disassembly.

Journal of virology - 1 Feb 1997

Wetzel J D, Wilson G J, Baer G S, Dunnigan L R, Wright J P, Tang D S, Dermody T S

Abstract excerpt

Reoviruses isolated from persistently infected cultures (PI viruses) can grow in the presence of ammonium chloride, a weak base that blocks acid-dependent proteolysis of viral outer-capsid proteins during viral entry into cells. We used reassortant viruses isolated from crosses of wild-type (wt)...

Topics

Animals
Capsid
Gene Expression Regulation, Viral
Genes, Viral
L Cells
Mice
Mutation
Reassortant Viruses
Reoviridae
Reoviridae Infections
Virus Assembly

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