Article
Genetic properties of temperature-sensitive folding mutants of the coat protein of phage P22.
Genetics - 1 Feb 1994
Gordon C L, King J
Abstract excerpt
Temperature-sensitive mutations fall into two general classes: those generating thermolabile proteins; and those generating defects in protein synthesis, folding or assembly. Temperature-sensitive mutations at 17 sites in the gene for the coat protein of Phage P22 are of the latter class, preventing the productive folding of the polypeptide chain at restrictive temperature. We show here that, though the coat...
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