Article
Selective T cell receptor Vbeta gene usage by alloreactive T cells responding to defined HLA-DR alleles.
Transplantation - 15 Nov 1996
Lobashevsky A, Kotb M, Gaber A O
Abstract excerpt
Previous studies have provided strong evidence for restricted Vbeta gene usage in response to DR synthetic peptides presented in context by self MHC molecules, i.e., via the indirect pathway of allorecognition. Although numerous studies have suggested a role for the T cell receptor (TCR) beta chain in the direct pathway of allorecognition, it is not clear whether a particular HLA allele elicits a consistent...
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