Article
New insights into the HCV quasispecies and compartmentalization.
Seminars in liver disease - 1 Nov 2011
Farci Patrizia
Abstract excerpt
Hepatitis C virus (HCV) is a hepatotropic RNA virus with an extraordinary propensity to persist in the vast majority of infected individuals. During replication, because of the inherent infidelity of the viral RNA polymerase, each progeny RNA genome contains mutations that lead to a continuous diversification of the viral population. Consequently, HCV circulates in vivo as a quasispecies, which is a dynamic...
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