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Article

Quasispecies in viral persistence and pathogenesis of hepatitis C virus.

Trends in microbiology - 1 Oct 1999

Forns X, Purcell R H, Bukh J

Abstract excerpt

Hepatitis C virus (HCV) is an important cause of chronic liver disease worldwide. This RNA virus circulates as a quasispecies and its genetic heterogeneity has been implicated in the lack of protective immunity against HCV and in its persistence following infection. HCV might escape from immune surveillance by developing mutations in proteins that are subject to immune pressure.

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Identifiers

PMID: 10498948
DOI: 10.1016/s0966-842x(99)01590-5

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