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Article

Genetic and environmental risk for lymphoma in boxer dogs.

Journal of veterinary internal medicine - 1 Sept 2020

Craun Kaitlyn, Ekena Joanne, Sacco James, Jiang Tao, Motsinger-Reif Alison, Trepanier Lauren A

Abstract excerpt

BACKGROUND: Non-Hodgkin lymphoma in humans is associated with environmental chemical exposures, and risk is enhanced by genetic variants in glutathione S-transferases (GST) enzymes. OBJECTIVE: We hypothesized that boxer dogs, a breed at risk for lymphoma, would have a higher prevalence of GST variants with predicted low activity, and greater accumulated DNA damage, compared to other breeds. We also hypothesized...

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Identifiers

PMID: 32667715
DOI: 10.1111/jvim.15849
PMCID: PMC7517848

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