Article
Wild-type p53-triggered apoptosis is inhibited by bcl-2 in a v-myc-induced T-cell lymphoma line.
Oncogene - 1 Dec 1993
Wang Y, Szekely L, Okan I, Klein G, Wiman K G
Abstract excerpt
Using a temperature sensitive p53 construct (ts p53), we have earlier shown that expression of wild-type (wt) p53 triggers apoptosis in a v-myc-induced T-cell lymphoma line that lacks endogenous p53, and in a Burkitt lymphoma line that carries mutant p53. We have suggested that apoptosis is elici...
Topics
- Animals
- Apoptosis
- Burkitt Lymphoma
- Cell Division
- Gene Expression Regulation, Neoplastic
- Genes, myc
- Lymphoma, T-Cell
- Mice
- Mutation
- Precipitin Tests
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- T-Lymphocytes
- Temperature
- Transfection
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53