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Article

Cell death regulation during multistep lymphomagenesis.

Cancer letters - 20 Jul 1995

Hsu B, Marin M C, McDonnell T J

Abstract excerpt

The three most common genetic abnormalities occurring in malignant lymphomas involve alterations resulting in the deregulated expression of the c-myc and bcl-2 oncogenes and the inactivation of the p53 tumor suppressor gene. Relevant strains of genetically engineered mice, including bcl-2-Ig and E mu-myc transgenic mice and p53 knockout mice, have been used to prospectively examine the regulation of apoptotic...

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Identifiers

PMID: 7621440
DOI: 10.1016/0304-3835(95)03836-l

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cell death regulation during multistep lymphomagenesis.PMID 7621440Read ↗

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Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation.Semantic proximity Read ↗

Genetic regulation of apoptosis in the mouse thymus.Semantic proximity Read ↗

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The cooperating mutation or "second hit" determines the immunologic visibility toward MYC-induced murine lymphomas.Semantic proximity Read ↗

Apoptosis is the essential target of selective pressure against p53, whereas loss of additional p53 functions facilitates carcinoma progression.Semantic proximity Read ↗

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Mutational analysis of transgenic mouse B cell lymphomas: indication of a Trp53-independent pathway in tumor progression.Semantic proximity Read ↗

Evidence that c-myc mediated apoptosis does not require wild-type p53 during lymphomagenesis.Semantic proximity Read ↗

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