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Article

Bcl-2 can promote p53-dependent senescence versus apoptosis without affecting the G1/S transition.

Biochemical and biophysical research communications - 25 Oct 2002

Rincheval Vincent, Renaud Flore, Lemaire Christophe, Godefroy Nelly, Trotot Pascale, Boulo Viviane, Mignotte Bernard, Vayssière Jean-Luc

Abstract excerpt

With the aim to identify events involved in the determination of p53-dependent apoptosis versus growth arrest, we used rat embryo fibroblasts expressing a temperature-sensitive mutant (tsA58) of the SV40 large tumour antigen (LT). Heat-inactivation of LT leads to p53 activation and commitment to a senescent-like state (REtsA15 cell line) or apoptosis (REtsAF cell line). We report that senescence is associated...

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Identifiers

PMID: 12387829
DOI: 10.1016/s0006-291x(02)02454-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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