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Article

The role of p53 in the normal control of cell proliferation.

Current opinion in cell biology - 1 Apr 1991

Milner J

Abstract excerpt

The regulation of cell proliferation involves p53. A mutant allele of p53, p53-Val135, has been found to be temperature-sensitive for function with separable suppressor and promoter effects on cell proliferation. These opposing suppressor and promoter functions of p53 correlate with two alternative, temperature-sensitive conformations of the p53-Val135 polypeptide.

Topics

Animals
Cell Division
Humans
Mutation
Phosphorylation
Protein Conformation
Temperature
Transcription, Genetic
Tumor Suppressor Protein p53

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1953903
DOI: 10.1016/0955-0674(91)90153-p

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1953903-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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